InnateDB Protein
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IDBP-36274.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ESPL1
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Protein Name
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extra spindle pole bodies homolog 1 (S. cerevisiae)
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Synonyms
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ESP1; SEPA;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000257934
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InnateDB Gene
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IDBG-36272 (ESPL1)
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Protein Structure
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Function |
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269PubMed:10411507, ECO:0000269PubMed:11509732}.
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Subcellular Localization |
Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
23
[view]
|
Protein-Protein |
23
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005314
Peptidase C50, separase
IPR027396
DsrEFH-like
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PFAM |
PF03568
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q14674
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PhosphoSite |
PhosphoSite-Q14674
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TrEMBL |
H3BRX7
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UniProt Splice Variant |
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Entrez Gene |
9700
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UniGene |
Hs.153479
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RefSeq |
NP_036423
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HUGO |
HGNC:16856
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OMIM |
604143
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CCDS |
CCDS8852
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HPRD |
06825
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IMGT |
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EMBL |
AC021072
AC073611
AY455930
D79987
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GenPept |
AAR18247
BAA11482
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