InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PJA2

Summary

InnateDB Protein

IDBP-36295.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PJA2

Protein Name

praja ring finger 2

Synonyms

Neurodap1; RNF131;

Species

Homo sapiens

Ensembl Protein

ENSP00000354775

InnateDB Gene

IDBG-36293 (PJA2)

Protein Structure

UniProt Annotation

Function

Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA- mediated long-term memory processes. {ECO:0000269PubMed:12036302, ECO:0000269PubMed:21423175}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21423175}. Cell membrane {ECO:0000269PubMed:21423175}. Endoplasmic reticulum membrane {ECO:0000269PubMed:21423175}; Peripheral membrane protein {ECO:0000269PubMed:21423175}. Golgi apparatus membrane {ECO:0000269PubMed:21423175}; Peripheral membrane protein {ECO:0000269PubMed:21423175}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus. Expressed in the postsynaptic density region of synapses (By similarity). Colocalizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0034236	protein kinase A catalytic subunit binding
GO:0034237	protein kinase A regulatory subunit binding
GO:0046872	metal ion binding

Biological Process

GO:0007616	long-term memory
GO:0010738	regulation of protein kinase A signaling
GO:0016567	protein ubiquitination

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0045211	postsynaptic membrane