InnateDB Protein
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IDBP-363128.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SON
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Protein Name
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SON DNA binding protein
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Synonyms
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BASS1; C21orf50; DBP-5; NREBP; SON3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000399783
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InnateDB Gene
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IDBG-2322 (SON)
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Protein Structure
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Function |
RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'- GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. {ECO:0000269PubMed:20581448, ECO:0000269PubMed:21504830}.
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Subcellular Localization |
Nucleus speckle {ECO:0000269PubMed:1424986, ECO:0000269PubMed:21504830}. Note=Colocalizes with the pre-mRNA splicing factor SRSF2.
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Disease Associations |
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Tissue Specificity |
Widely expressed, with the higher expression seen in leukocyte and heart.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
73
[view]
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Protein-Protein |
72
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR017986
WD40-repeat-containing domain
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P18583
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PhosphoSite |
PhosphoSite-P18583
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
6651
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UniGene |
Hs.656725
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RefSeq |
XP_006724107
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HUGO |
HGNC:11183
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OMIM |
182465
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CCDS |
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HPRD |
01678
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IMGT |
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EMBL |
AB028942
AF139897
AF161428
AF161430
AF380179
AF380180
AF380181
AF380182
AF380183
AF380184
AF435977
AK024752
AP000303
AP000304
AY026895
BC002422
CH471079
M36428
X63071
X63751
X63753
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GenPept |
AAA36624
AAD50078
AAF28988
AAF28990
AAH02422
AAK07692
AAL30810
AAL34497
AAL34498
AAL34499
AAL34500
AAL34501
AAL34502
BAA82971
BAB14985
CAA44793
CAA45282
CAC69885
EAX09814
EAX09818
EAX09821
EAX09823
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