InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNF216

Summary

InnateDB Protein

IDBP-363145.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF216

Protein Name

ring finger protein 216

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000404602

InnateDB Gene

IDBG-7724 (RNF216)

Protein Structure

UniProt Annotation

Function

Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down- regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3/ZIN inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis. {ECO:0000269PubMed:15107846, ECO:0000269PubMed:19893624}.

Subcellular Localization

Cytoplasm.

Disease Associations

Gordon Holmes syndrome (GDHS) [MIM:212840]: A disease characterized by cerebellar symptoms and signs of sex steroid deficiency. Clinical features include cerebellar and brain stem atrophy, cerebellar ataxia, hypothalamic LHRH deficiency, hypogonadotrophic hypogonadism, lack of secondary sexual characteristics, and infertility. {ECO:0000269PubMed:23656588}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitous, with the highest levels of expression in testis and peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0006915	apoptotic process
GO:0016032	viral process
GO:0032648	regulation of interferon-beta production
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0050691	regulation of defense response to virus by host
GO:0070936	protein K48-linked ubiquitination