Version 5.4
Homo sapiens Gene: RNF216
Summary
InnateDB Gene IDBG-7724.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF216
Gene Name ring finger protein 216
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000011275
Encoded Proteins
IDBP-7728
ring finger protein 216
IDBP-7734
ring finger protein 216
IDBP-363145
ring finger protein 216
IDBP-363163
ring finger protein 216
IDBP-363170
ring finger protein 216
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:5620047-5781739
Strand Reverse strand
Band p22.1
Transcripts
ENST00000389902 ENSP00000374552
ENST00000389900 ENSP00000374550
ENST00000425013 ENSP00000404602
ENST00000411812 ENSP00000409837
ENST00000416985 ENSP00000396829
ENST00000469375
ENST00000484458
ENST00000479541
ENST00000476345
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0006915 apoptotic process
GO:0016032 viral process
GO:0032648 regulation of interferon-beta production
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0050691 regulation of defense response to virus by host
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000045078
View Gene Order
ENSBTAG00000017175
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.487458
RefSeq NM_207111 NM_207116 XM_005249785
HUGO
OMIM
CCDS CCDS34594 CCDS34595
HPRD 15550
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca