InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLCH2

Summary

InnateDB Protein

IDBP-363162.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLCH2

Protein Name

phospholipase C, eta 2

Synonyms

PLC-eta2; PLCeta2; PLCL4;

Species

Homo sapiens

Ensembl Protein

ENSP00000397289

InnateDB Gene

IDBG-86294 (PLCH2)

Protein Structure

UniProt Annotation

Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cell membrane. Note=Localized predominantly at the plasma membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in retina and kidney. {ECO:0000269PubMed:16107206}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0008150	biological_process
GO:0016042	lipid catabolic process
GO:0035556	intracellular signal transduction
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005575	cellular_component
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology domain
IPR002048 EF-hand domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM