Version 5.4
Homo sapiens Gene: PLCH2
Summary
InnateDB Gene IDBG-86294.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLCH2
Gene Name phospholipase C, eta 2
Synonyms PLC-eta2; PLCeta2; PLCL4
Species Homo sapiens
Ensembl Gene ENSG00000149527
Encoded Proteins
IDBP-86302
phospholipase C, eta 2
IDBP-86308
phospholipase C, eta 2
IDBP-363162
phospholipase C, eta 2
IDBP-363201
phospholipase C, eta 2
IDBP-807656
phospholipase C, eta 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005 [PubMed 16107206]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:2425980-2505530
Strand Forward strand
Band p36.32
Transcripts
ENST00000378486 ENSP00000367747
ENST00000343889
ENST00000278878 ENSP00000278878
ENST00000449969 ENSP00000397289
ENST00000419816 ENSP00000389803
ENST00000473964
ENST00000462379
ENST00000609981 ENSP00000476436
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004629 phospholipase C activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0008150 biological_process
GO:0008152 metabolic process
GO:0016042 lipid catabolic process
GO:0035556 intracellular signal transduction
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0046488 phosphatidylinositol metabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029055
View Gene Order
ENSBTAG00000002464
Not yet available
Pathways
NETPATH
REACTOME
REACT_150312
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.170156
RefSeq NM_014638 XM_006711054 XM_006711055 XM_006724949 XM_006724950 XM_006724951
HUGO
OMIM
CCDS CCDS59959
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca