Version 5.4
| Homo sapiens Protein: ADAM28 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-364051.5 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | ADAM28 | ||||||||
| Protein Name | ADAM metallopeptidase domain 28 | ||||||||
| Synonyms | ADAM 28; ADAM23; eMDC II; eMDCII; MDC-L; MDC-Lm; MDC-Ls; MDCL; | ||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000393699 | ||||||||
| InnateDB Gene | IDBG-12310 (ADAM28) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation. | ||||||||
| Subcellular Localization | Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially in spleen. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR001590
Peptidase M12B, ADAM/reprolysin IPR001762 Blood coagulation inhibitor, Disintegrin IPR002870 Peptidase M12B, propeptide IPR006586 ADAM, cysteine-rich |
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| PFAM |
PF01421
PF00200 PF01562 PF08516 |
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| PRINTS |
PR00289
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| PIRSF | |||||||||
| SMART |
SM00050
SM00608 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9UKQ2 | ||||||||
| PhosphoSite | PhosphoSite-Q9UKQ2 | ||||||||
| TrEMBL | E5RGY1 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 10863 | ||||||||
| UniGene | Hs.639953 | ||||||||
| RefSeq | NP_068547 | ||||||||
| HUGO | HGNC:206 | ||||||||
| OMIM | 606188 | ||||||||
| CCDS | CCDS47830 | ||||||||
| HPRD | 08391 | ||||||||
| IMGT | |||||||||
| EMBL | AC044891 AC120193 AF137334 AF137335 AJ242015 AK293382 BC136478 CH471080 | ||||||||
| GenPept | AAD25099 AAD25100 AAI36479 BAG56894 CAB42085 EAW63609 | ||||||||