Version 5.4
Homo sapiens Gene: ADAM28
Summary
InnateDB Gene IDBG-12310.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM28
Gene Name ADAM metallopeptidase domain 28
Synonyms ADAM 28; ADAM23; eMDC II; eMDCII; MDC-L; MDC-Lm; MDC-Ls; MDCL
Species Homo sapiens
Ensembl Gene ENSG00000042980
Encoded Proteins
IDBP-12312
ADAM metallopeptidase domain 28
IDBP-364051
ADAM metallopeptidase domain 28
IDBP-475700
ADAM metallopeptidase domain 28
IDBP-485408
ADAM metallopeptidase domain 28
IDBP-477422
ADAM metallopeptidase domain 28
IDBP-476910
ADAM metallopeptidase domain 28
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. Alternative splicing results in two transcript variants. The shorter version encodes a secreted isoform, while the longer version encodes a transmembrane isoform. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:24294040-24359018
Strand Forward strand
Band p21.2
Transcripts
ENST00000265769 ENSP00000265769
ENST00000437154 ENSP00000393699
ENST00000520448 ENSP00000430085
ENST00000523379 ENSP00000431108
ENST00000523440
ENST00000518516
ENST00000521110
ENST00000521629 ENSP00000429484
ENST00000523236
ENST00000518326 ENSP00000430094
ENST00000520665
ENST00000518737
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007229 integrin-mediated signaling pathway
GO:0007283 spermatogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000014725
View Gene Order
ENSBTAG00000037929
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.174030 Hs.388903 Hs.601702 Hs.610301 Hs.611604 Hs.622063 Hs.639953
RefSeq NM_014265 NM_021777 XM_005273382 XM_006716274
HUGO
OMIM
CCDS CCDS34865 CCDS47830
HPRD 08391
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca