Version 5.4
Homo sapiens Protein: FHOD1
Summary
InnateDB Protein IDBP-36409.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FHOD1
Protein Name formin homology 2 domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000258201
InnateDB Gene IDBG-36407 (FHOD1)
Protein Structure
UniProt Annotation
Function Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. {ECO:0000269PubMed:14576350, ECO:0000269PubMed:15878344, ECO:0000269PubMed:18694941}.
Subcellular Localization Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Note=Predominantly cytoplasmic.
Disease Associations
Tissue Specificity Ubiquitous. Highly expressed in spleen.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005488 binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051496 positive regulation of stress fiber assembly
Cellular Component
GO:0001725 stress fiber
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0032059 bleb
Protein Structure and Domains
PDB ID
InterPro IPR015425 Formin, FH2 domain
IPR016024 Armadillo-type fold
PFAM PF02181
PRINTS
PIRSF
SMART SM00498
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y613
PhosphoSite PhosphoSite-Q9Y613
TrEMBL
UniProt Splice Variant
Entrez Gene 29109
UniGene Hs.95231
RefSeq NP_037373
HUGO HGNC:17905
OMIM 606881
CCDS CCDS10834
HPRD 06049
IMGT
EMBL AB041046 AB209584 AF113615 AY192154 BC033084
GenPept AAD39906 AAH33084 AAO38757 BAD06250 BAD92821

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca