Version 5.4
Homo sapiens Gene: FHOD1
Summary
InnateDB Gene IDBG-36407.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FHOD1
Gene Name formin homology 2 domain containing 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135723
Encoded Proteins
IDBP-36409
formin homology 2 domain containing 1
IDBP-752828
IDBP-745224
IDBP-748989
IDBP-754103
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:67229387-67247658
Strand Reverse strand
Band q22.1
Transcripts
ENST00000258201 ENSP00000258201
ENST00000569085
ENST00000568595 ENSP00000464011
ENST00000567509 ENSP00000462988
ENST00000567752
ENST00000566006
ENST00000561922 ENSP00000458085
ENST00000567561 ENSP00000462807
ENST00000562266
ENST00000569888
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005488 binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051496 positive regulation of stress fiber assembly
Cellular Component
GO:0001725 stress fiber
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0032059 bleb
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000014778
View Gene Order
ENSBTAG00000032427
Not yet available
Cross-References
SwissProt
TrEMBL J3KTH7
UniProt Splice Variant
Entrez Gene 29109
UniGene Hs.95231
RefSeq NM_013241 XM_006721180
HUGO HGNC:17905
OMIM 606881
CCDS CCDS10834
HPRD 06049
IMGT
EMBL AC040160
GenPept
RNA Seq Atlas 29109

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca