Version 5.4
Homo sapiens Protein: RBM17
Summary
InnateDB Protein IDBP-364218.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBM17
Protein Name RNA binding motif protein 17
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000388638
InnateDB Gene IDBG-50666 (RBM17)
Protein Structure
UniProt Annotation
Function Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. {ECO:0000269PubMed:12015979, ECO:0000269PubMed:17589525}.
Subcellular Localization Nucleus {ECO:0000269PubMed:9731529}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000380 alternative mRNA splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000467 G-patch domain
IPR003954 RNA recognition motif domain, eukaryote
IPR016967 Splicing factor, SPF45
PFAM PF01585
PRINTS
PIRSF PIRSF031066
SMART SM00443
SM00361
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96I25
PhosphoSite PhosphoSite-Q96I25
TrEMBL Q5W011
UniProt Splice Variant
Entrez Gene 84991
UniGene Hs.620308
RefSeq NP_001139019
HUGO HGNC:16944
OMIM 606935
CCDS CCDS7077
HPRD 09501
IMGT
EMBL AF542550 AK314952 AL157395 BC007871 BC009064 BC039322 CH471072
GenPept AAH07871 AAH09064 AAH39322 AAQ09533 BAG37457 EAW86405 EAW86410

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca