InnateDB Protein
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IDBP-36440.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC5A12
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Protein Name
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solute carrier family 5 (sodium/glucose cotransporter), member 12
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000280467
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InnateDB Gene
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IDBG-36436 (SLC5A12)
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Protein Structure
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Function |
Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D- hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity). {ECO:0000250}.
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Subcellular Localization |
Apical cell membrane {ECO:0000269PubMed:17692818}; Multi-pass membrane protein {ECO:0000269PubMed:17692818}. Note=Detected at the brush border membrane of the kidney. Colocalizes with viementin in Mueller cells (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001734
Sodium/solute symporter
IPR019900
Sodium/solute symporter, subgroup
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PFAM |
PF00474
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q1EHB4
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PhosphoSite |
PhosphoSite-Q1EHB4
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TrEMBL |
E9PLZ7
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UniProt Splice Variant |
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Entrez Gene |
159963
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UniGene |
Hs.708580
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RefSeq |
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HUGO |
HGNC:28750
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OMIM |
612455
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CCDS |
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HPRD |
15395
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IMGT |
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EMBL |
AC083755
AY299482
BC049207
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GenPept |
AAH49207
AAQ73572
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