Version 5.4
Homo sapiens Protein: SLC5A12
Summary
InnateDB Protein IDBP-36440.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC5A12
Protein Name solute carrier family 5 (sodium/glucose cotransporter), member 12
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000280467
InnateDB Gene IDBG-36436 (SLC5A12)
Protein Structure
UniProt Annotation
Function Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D- hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity). {ECO:0000250}.
Subcellular Localization Apical cell membrane {ECO:0000269PubMed:17692818}; Multi-pass membrane protein {ECO:0000269PubMed:17692818}. Note=Detected at the brush border membrane of the kidney. Colocalizes with viementin in Mueller cells (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015293 symporter activity
Biological Process
GO:0006810 transport
GO:0006814 sodium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001734 Sodium/solute symporter
IPR019900 Sodium/solute symporter, subgroup
PFAM PF00474
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1EHB4
PhosphoSite PhosphoSite-Q1EHB4
TrEMBL E9PLZ7
UniProt Splice Variant
Entrez Gene 159963
UniGene Hs.708580
RefSeq
HUGO HGNC:28750
OMIM 612455
CCDS
HPRD 15395
IMGT
EMBL AC083755 AY299482 BC049207
GenPept AAH49207 AAQ73572

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca