Version 5.4
Homo sapiens Gene: SLC5A12
Summary
InnateDB Gene IDBG-36436.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC5A12
Gene Name solute carrier family 5 (sodium/glucose cotransporter), member 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000148942
Encoded Proteins
IDBP-36440
solute carrier family 5 (sodium/glucose cotransporter), member 12
IDBP-238393
solute carrier family 5 (sodium/glucose cotransporter), member 12
IDBP-602295
solute carrier family 5 (sodium/glucose cotransporter), member 12
IDBP-587640
solute carrier family 5 (sodium/glucose cotransporter), member 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal tubule and by the high-affinity Na(+)-coupled lactate transporter SLC5A8 (MIM 608044) in the distal proximal tubule (Gopal et al., 2007 [PubMed 17692818]).[supplied by OMIM, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:26667019-26723427
Strand Reverse strand
Band p14.2
Transcripts
ENST00000280467 ENSP00000280467
ENST00000396005 ENSP00000379326
ENST00000527405 ENSP00000436011
ENST00000533617 ENSP00000435053
ENST00000528822
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015293 symporter activity
Biological Process
GO:0006810 transport
GO:0006814 sodium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041644
View Gene Order
ENSBTAG00000021858
Not yet available
Cross-References
SwissProt
TrEMBL E9PLZ7
UniProt Splice Variant
Entrez Gene 159963
UniGene Hs.148907 Hs.607356 Hs.708580
RefSeq NM_178498 XM_006718155 XM_006718157
HUGO HGNC:28750
OMIM 612455
CCDS CCDS7860
HPRD 15395
IMGT
EMBL AC083755
GenPept
RNA Seq Atlas 159963

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca