InnateDB Protein
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IDBP-364772.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GGT2
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Protein Name
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gamma-glutamyltransferase 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000402035
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InnateDB Gene
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IDBG-1970 (GGT2)
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Protein Structure
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Function |
Isoform 1, isoform 2 and isoform 3 lack catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically active heterodimer. {ECO:0000269PubMed:23682772}.
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Subcellular Localization |
Cytoplasm, perinuclear region {ECO:0000269PubMed:23682772}. Endoplasmic reticulum {ECO:0000269PubMed:23682772}. Note=Co-localizes with calnexin in the endoplasmic reticulum.
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Disease Associations |
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Tissue Specificity |
Highly expressed in fetal and adult kidney and liver.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0003840
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gamma-glutamyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000101
Gamma-glutamyltranspeptidase
IPR029055
Nucleophile aminohydrolases, N-terminal
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PFAM |
PF01019
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PRINTS |
PR01210
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P36268
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PhosphoSite |
PhosphoSite-P36268
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TrEMBL |
C9JIY6
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UniProt Splice Variant |
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Entrez Gene |
728441
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UniGene |
Hs.595809
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RefSeq |
XP_006724993
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HUGO |
HGNC:4251
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OMIM |
137181
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AA632626
AP000356
AP000550
BG743316
M30474
M30475
M30476
M30477
M30478
M30479
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GenPept |
AAA52548
AAA52765
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