Version 5.4
Homo sapiens Protein: PRNP
Summary
InnateDB Protein IDBP-364807.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRNP
Protein Name prion protein
Synonyms AltPrP; ASCR; CD230; CJD; GSS; KURU; p27-30; PRIP; PrP; PrP27-30; PrP33-35C; PrPc;
Species Homo sapiens
Ensembl Protein ENSP00000411599
InnateDB Gene IDBG-49833 (PRNP)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 94 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Experimentally validated
Total 94 [view]
Protein-Protein 93 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0051260 protein homooligomerization
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000817 Prion protein
IPR022416 Prion/Doppel protein, beta-ribbon domain
IPR025860 Major prion protein N-terminal domain
PFAM PF00377
PF11587
PRINTS PR00341
PIRSF
SMART SM00157
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL X6RKS3
UniProt Splice Variant
Entrez Gene 5621
UniGene Hs.472010
RefSeq
HUGO HGNC:9449
OMIM 176640
CCDS
HPRD 01453
IMGT
EMBL AL133396
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca