InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HIC2

Summary

InnateDB Protein

IDBP-364869.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HIC2

Protein Name

hypermethylated in cancer 2

Synonyms

HRG22; ZBTB30; ZNF907;

Species

Homo sapiens

Ensembl Protein

ENSP00000387757

InnateDB Gene

IDBG-2014 (HIC2)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Highest levels in cerebellum.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR007087 Zinc finger, C2H2
IPR011333 BTB/POZ fold
IPR013069 BTB/POZ
IPR015880 Zinc finger, C2H2-like

PFAM

PF00096
PF00651

PRINTS

PIRSF

SMART

SM00225
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96JB3

PhosphoSite

PhosphoSite-Q96JB3

TrEMBL

UniProt Splice Variant

Entrez Gene

23119

UniGene

Hs.632767

RefSeq

XP_005261452

HUGO

HGNC:18595

OMIM

607712

CCDS

CCDS13789

HPRD

07412

IMGT

EMBL

AB028943 AF349035 AJ313204 AL162003 AP000557 BC094787 CR456377

GenPept

AAH94787 AAK72951 BAA82972 CAB82344 CAC70715 CAG30263