Version 5.4
Homo sapiens Protein: THSD7A
Summary
InnateDB Protein IDBP-365177.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THSD7A
Protein Name thrombospondin, type I, domain containing 7A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000406482
InnateDB Gene IDBG-8643 (THSD7A)
Protein Structure
UniProt Annotation
Function The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism. {ECO:0000269PubMed:22194972}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:22194972}; Single-pass type I membrane protein {ECO:0000269PubMed:22194972}. Secreted {ECO:0000269PubMed:22194972}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001525 angiogenesis
GO:0030154 cell differentiation
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000884 Thrombospondin, type 1 repeat
PFAM PF00090
PRINTS
PIRSF
SMART SM00209
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UPZ6
PhosphoSite PhosphoSite-Q9UPZ6
TrEMBL
UniProt Splice Variant
Entrez Gene 221981
UniGene Hs.120855
RefSeq NP_056019
HUGO HGNC:22207
OMIM 612249
CCDS CCDS47543
HPRD
IMGT
EMBL AB023177 AC004141 AC004160 AC004614 AC010908 AC073109 AK092252
GenPept BAA76804

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca