InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CELF2

Summary

InnateDB Protein

IDBP-365280.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CELF2

Protein Name

CUGBP, Elav-like family member 2

Synonyms

BRUNOL3; CUGBP2; ETR-3; ETR3; NAPOR;

Species

Homo sapiens

Ensembl Protein

ENSP00000404834

InnateDB Gene

IDBG-52770 (CELF2)

Protein Structure

UniProt Annotation

Function

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre- mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Accumulates in the cytoplasm after ionizing radiation (By similarity). Colocalizes with APOBEC1 and A1CF. RNA-binding activity is detected in both nuclear and cytoplasmic compartments. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in frontal cortex. Isoform 1 is expressed in brain and lung. Isoform 2 is expressed in heart, brain, placenta, lung, liver, kidney, skeletal muscle and pancreas. Isoform 4 is expressed in heart, lung, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:10524244, ECO:0000269PubMed:10893231, ECO:0000269PubMed:11158314, ECO:0000269PubMed:11414768, ECO:0000269PubMed:16862542}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006396	RNA processing
GO:0006397	mRNA processing
GO:0008016	regulation of heart contraction

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain
IPR002343 Paraneoplastic encephalomyelitis antigen

PFAM

PF00076

PRINTS

PR00961

PIRSF

SMART

SM00360

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95319

PhosphoSite

PhosphoSite-O95319

TrEMBL

B4DIB6

UniProt Splice Variant

Entrez Gene

10659

UniGene

Hs.620907

RefSeq

NP_001020247

HUGO

HGNC:2550

OMIM

602538

CCDS

CCDS41488

HPRD

03964

IMGT

EMBL

AC026887 AF036956 AF090693 AF090694 AF295063 AF295064 AF295065 AF295066 AF295067 AF295068 AF314199 AF432906 AK295511 AK316354 AL136320 AL136369 AL138769 AL157704 AL162408 BC036391 CH471072 U69546

GenPept

AAB09040 AAD02074 AAD13760 AAD13761 AAH36391 AAK72223 AAK72224 AAK92699 AAL27627 BAG58428 BAH14725 CAH70230 CAI20169 EAW86346