InnateDB Protein
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IDBP-365526.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IFT74
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Protein Name
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intraflagellar transport 74 homolog (Chlamydomonas)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000389224
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InnateDB Gene
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IDBG-55009 (IFT74)
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Protein Structure
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Function |
Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis. {ECO:0000269PubMed:23990561}.
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Subcellular Localization |
Cell projection, cilium. Cytoplasmic vesicle. Note=Localizes along primary cilia at interphase and around the basal body/centriole at interphase and mitosis.
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Disease Associations |
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Tissue Specificity |
Highly expressed in adult and fetal kidney and expressed at lower level in adult heart, placenta, lung, liver and pancreas, and in fetal heart, lung and liver. Little to no expression was detected in adult brain and skeletal muscle or in fetal brain, thymus and spleen. {ECO:0000269PubMed:11683410}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96LB3
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PhosphoSite |
PhosphoSite-Q96LB3
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TrEMBL |
E5RH29
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UniProt Splice Variant |
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Entrez Gene |
80173
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UniGene |
Hs.145402
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RefSeq |
NP_001092693
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HUGO |
HGNC:21424
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OMIM |
608040
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CCDS |
CCDS43793
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HPRD |
09727
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IMGT |
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EMBL |
AK023707
AK026274
AL355432
AL356133
AY040325
BC107742
BC113524
BX436367
CH471071
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GenPept |
AAI07743
AAI13525
AAK77221
BAB14650
BAB15423
CAH72643
EAW58573
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