InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDPK1

Summary

InnateDB Protein

IDBP-365619.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDPK1

Protein Name

3-phosphoinositide dependent protein kinase-1

Synonyms

PDK1; PDPK2; PRO0461;

Species

Homo sapiens

Ensembl Protein

ENSP00000395357

InnateDB Gene

IDBG-10648 (PDPK1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 94 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	94 [view]
Protein-Protein	93 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004676	3-phosphoinositide-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016004	phospholipase activator activity
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0043274	phospholipase binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007596	blood coagulation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010518	positive regulation of phospholipase activity
GO:0016477	cell migration
GO:0018107	peptidyl-threonine phosphorylation
GO:0019722	calcium-mediated signaling
GO:0030036	actin cytoskeleton organization
GO:0030168	platelet activation
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031295	T cell costimulation
GO:0032148	activation of protein kinase B activity
GO:0032869	cellular response to insulin stimulus
GO:0035556	intracellular signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response
GO:0046777	protein autophosphorylation
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0050852	T cell receptor signaling pathway
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0090004	positive regulation of establishment of protein localization to plasma membrane
GO:0097191	extrinsic apoptotic signaling pathway

Cellular Component

GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt