Version 5.4
Homo sapiens Gene: PDPK1
Summary
InnateDB Gene IDBG-10648.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDPK1
Gene Name 3-phosphoinositide dependent protein kinase-1
Synonyms PDK1; PDPK2; PRO0461
Species Homo sapiens
Ensembl Gene ENSG00000140992
Encoded Proteins
IDBP-10650
3-phosphoinositide dependent protein kinase-1
IDBP-10654
3-phosphoinositide dependent protein kinase-1
IDBP-10656
3-phosphoinositide dependent protein kinase-1
IDBP-365619
3-phosphoinositide dependent protein kinase-1
IDBP-752000
IDBP-753612
IDBP-746421
IDBP-754064
IDBP-749659
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16:2537964-2603188
Strand Forward strand
Band p13.3
Transcripts
ENST00000342085 ENSP00000344220
ENST00000268673 ENSP00000268673
ENST00000389224 ENSP00000373876
ENST00000441549 ENSP00000395357
ENST00000462923
ENST00000474706 ENSP00000455025
ENST00000492021 ENSP00000455684
ENST00000461815 ENSP00000455551
ENST00000491073
ENST00000460496
ENST00000464702
ENST00000471311
ENST00000478708 ENSP00000455438
ENST00000561962
ENST00000566659 ENSP00000455492
ENST00000569721
ENST00000570136
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 94 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 94 [view]
Protein-Protein 93 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004676 3-phosphoinositide-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005158 insulin receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016004 phospholipase activator activity
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0043274 phospholipase binding
Biological Process
GO:0003323 type B pancreatic cell development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0006972 hyperosmotic response
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010518 positive regulation of phospholipase activity
GO:0010594 regulation of endothelial cell migration
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0016477 cell migration
GO:0018107 peptidyl-threonine phosphorylation
GO:0019722 calcium-mediated signaling
GO:0030036 actin cytoskeleton organization
GO:0030168 platelet activation
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031295 T cell costimulation
GO:0032148 activation of protein kinase B activity
GO:0032869 cellular response to insulin stimulus
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043304 regulation of mast cell degranulation
GO:0045087 innate immune response
GO:0046777 protein autophosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048041 focal adhesion assembly
GO:0050852 T cell receptor signaling pathway
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
GO:0097191 extrinsic apoptotic signaling pathway
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0042995 cell projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024122
View Gene Order
ENSBTAG00000034436
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_12
BCR pathway
NetPath_23
TSH pathway
NetPath_147
IL11 pathway
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12555
Downstream TCR signaling pathway
REACT_19405
CTLA4 inhibitory signaling pathway
REACT_19358
CD28 dependent PI3K/Akt signaling pathway
REACT_19183
CD28 co-stimulation pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_15523
Integrin alphaIIb beta3 signaling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_12464
PI3K/AKT activation pathway
REACT_790
Activation of PKB pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_20510
RSK activation pathway
REACT_20568
CREB phosphorylation through the activation of Ras pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_163994
FCERI mediated NF-kB activation pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_12526
TCR signaling pathway
REACT_13685
Neuronal System pathway
REACT_12529
Signaling by VEGF pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_20593
Post NMDA receptor activation events pathway
REACT_332
IRS-mediated signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228024
VEGFR2 mediated cell proliferation pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_762
IRS-related events pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa05223
Non-small cell lung cancer pathway
hsa05213
Endometrial cancer pathway
hsa04910
Insulin signaling pathway pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa03320
PPAR signaling pathway pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04960
Aldosterone-regulated sodium reabsorption pathway
hsa05145
Toxoplasmosis pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
INOH website
IGF1 signaling pathway pathway
INOH website
PDGF signaling pathway pathway
PID NCI
pi3kplctrkpathway
Trk receptor signaling mediated by PI3K and PLC-gamma
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pi3kcipathway
Class I PI3K signaling events
il8cxcr2_pathway
IL8- and CXCR2-mediated signaling events
pi3kciaktpathway
Class I PI3K signaling events mediated by Akt
cxcr4_pathway
CXCR4-mediated signaling events
il8cxcr1_pathway
IL8- and CXCR1-mediated signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
erbb1_downstream_pathway
ErbB1 downstream signaling
mtor_4pathway
mTOR signaling pathway
igf1_pathway
IGF1 pathway
fgf_pathway
FGF signaling pathway
bcr_5pathway
BCR signaling pathway
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
tgfbrpathway
TGF-beta receptor signaling
cxcr3pathway
CXCR3-mediated signaling events
vegfr1_pathway
VEGFR1 specific signals
insulin_pathway
Insulin Pathway
faspathway
FAS (CD95) signaling pathway
Cross-References
SwissProt
TrEMBL H3BQA3
UniProt Splice Variant
Entrez Gene 5170
UniGene Hs.459691 Hs.641816 Hs.709110
RefSeq NM_001261816 NM_002613 NM_031268 XM_005255356
HUGO HGNC:8816
OMIM 605213
CCDS CCDS10472 CCDS10473 CCDS58411
HPRD 05556
IMGT
EMBL AC093525 AC141586
GenPept
RNA Seq Atlas 101060747 5170

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca