Version 5.4
Homo sapiens Protein: BTN2A2
Summary
InnateDB Protein IDBP-365756.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BTN2A2
Protein Name butyrophilin, subfamily 2, member A2
Synonyms BT2.2; BTF2; BTN2.2;
Species Homo sapiens
Ensembl Protein ENSP00000394241
InnateDB Gene IDBG-69203 (BTN2A2)
Protein Structure
UniProt Annotation
Function Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney. {ECO:0000269PubMed:9149941}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0031324 negative regulation of cellular metabolic process
GO:0046007 negative regulation of activated T cell proliferation
GO:0050710 negative regulation of cytokine secretion
Cellular Component
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00406
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WVV5
PhosphoSite PhosphoSite-Q8WVV5
TrEMBL C9JAJ6
UniProt Splice Variant
Entrez Gene 10385
UniGene Hs.605482
RefSeq NP_001184169
HUGO HGNC:1137
OMIM 613591
CCDS CCDS56402
HPRD 12545
IMGT
EMBL AK289883 AK293526 AK298570 AL021917 BC014021 BC017497 CH471087 U90550
GenPept AAB53428 AAH14021 AAH17497 BAF82572 BAG57008 BAG60763 CAC03425 EAW55565

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca