Version 5.4
Homo sapiens Gene: BTN2A2
Summary
InnateDB Gene IDBG-69203.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BTN2A2
Gene Name butyrophilin, subfamily 2, member A2
Synonyms BT2.2; BTF2; BTN2.2
Species Homo sapiens
Ensembl Gene ENSG00000124508
Encoded Proteins
IDBP-69205
butyrophilin, subfamily 2, member A2
IDBP-69207
butyrophilin, subfamily 2, member A2
IDBP-365753
butyrophilin, subfamily 2, member A2
IDBP-365756
butyrophilin, subfamily 2, member A2
IDBP-477881
butyrophilin, subfamily 2, member A2
IDBP-478375
butyrophilin, subfamily 2, member A2
IDBP-481407
butyrophilin, subfamily 2, member A2
IDBP-482223
butyrophilin, subfamily 2, member A2
IDBP-477423
butyrophilin, subfamily 2, member A2
IDBP-473594
butyrophilin, subfamily 2, member A2
IDBP-482310
butyrophilin, subfamily 2, member A2
IDBP-481824
butyrophilin, subfamily 2, member A2
IDBP-476035
butyrophilin, subfamily 2, member A2
IDBP-484473
butyrophilin, subfamily 2, member A2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:26383096-26394874
Strand Forward strand
Band p22.2
Transcripts
ENST00000356709 ENSP00000349143
ENST00000352867 ENSP00000337117
ENST00000416795 ENSP00000399308
ENST00000432533 ENSP00000394241
ENST00000469230 ENSP00000417472
ENST00000490025 ENSP00000418965
ENST00000467485
ENST00000493275 ENSP00000418857
ENST00000472507 ENSP00000419226
ENST00000482536 ENSP00000419451
ENST00000482842 ENSP00000417676
ENST00000482636
ENST00000471116 ENSP00000418657
ENST00000494184 ENSP00000417511
ENST00000483410 ENSP00000418176
ENST00000495632 ENSP00000417129
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0031324 negative regulation of cellular metabolic process
GO:0046007 negative regulation of activated T cell proliferation
GO:0050710 negative regulation of cytokine secretion
Cellular Component
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000053216
View Gene Order
Cross-References
SwissProt
TrEMBL F8WC65
UniProt Splice Variant
Entrez Gene 10385
UniGene Hs.373938 Hs.605482
RefSeq NM_001197237 NM_001197238 NM_001197239 NM_001197240 NM_006995 NM_181531 XM_005248797 XM_005248798 XM_006714956
HUGO HGNC:1137
OMIM 613591
CCDS CCDS4606 CCDS4607 CCDS56401 CCDS56402 CCDS56403
HPRD 12545
IMGT
EMBL AL021917
GenPept
RNA Seq Atlas 10385

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca