Version 5.4
Homo sapiens Protein: PRSS21
Summary
InnateDB Protein IDBP-365812.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRSS21
Protein Name protease, serine, 21 (testisin)
Synonyms ESP-1; ESP1; TEST1; TESTISIN;
Species Homo sapiens
Ensembl Protein ENSP00000407741
InnateDB Gene IDBG-11066 (PRSS21)
Protein Structure
UniProt Annotation
Function Could regulate proteolytic events associated with testicular germ cell maturation.
Subcellular Localization Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed predominantly in premeiotic testicular germ cells, mostly late pachytene and diplotene spermatocytes.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y6M0
PhosphoSite PhosphoSite-Q9Y6M0
TrEMBL
UniProt Splice Variant
Entrez Gene 10942
UniGene
RefSeq NP_659206
HUGO HGNC:9485
OMIM 608159
CCDS CCDS45388
HPRD 07082
IMGT
EMBL AB031329 AB031330 AB031331 AF058300 AF058301 AY359034 BC074999 BC075000
GenPept AAD41588 AAF79019 AAF79020 AAH74999 AAH75000 AAQ89393 BAA83520 BAA83521 BAA89532

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca