Version 5.4
Homo sapiens Gene: PRSS21
Summary
InnateDB Gene IDBG-11066.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRSS21
Gene Name protease, serine, 21 (testisin)
Synonyms ESP-1; ESP1; TEST1; TESTISIN
Species Homo sapiens
Ensembl Gene ENSG00000007038
Encoded Proteins
IDBP-11068
protease, serine, 21 (testisin)
IDBP-365812
protease, serine, 21 (testisin)
IDBP-749485
IDBP-746877
IDBP-748772
IDBP-745672
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:2817180-2826304
Strand Forward strand
Band p13.3
Transcripts
ENST00000005995 ENSP00000005995
ENST00000450020 ENSP00000407741
ENST00000571141
ENST00000570629 ENSP00000460417
ENST00000575739
ENST00000570594 ENSP00000459664
ENST00000574265 ENSP00000460351
ENST00000575199
ENST00000577043
ENST00000574813 ENSP00000458341
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007283 spermatogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024116
View Gene Order
ENSBTAG00000015045
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001270452 NM_006799 NM_144956 NM_144957 XM_005255051
HUGO
OMIM
CCDS CCDS10478 CCDS45388
HPRD 07082
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca