Version 5.4
Homo sapiens Protein: SENP3
Summary
InnateDB Protein IDBP-365860.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SENP3
Protein Name SUMO1/sentrin/SMT3 specific peptidase 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000403712
InnateDB Gene IDBG-25742 (SENP3)
Protein Structure
UniProt Annotation
Function Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. {ECO:0000269PubMed:15743823, ECO:0000269PubMed:16608850, ECO:0000269PubMed:18259216, ECO:0000269PubMed:18946085, ECO:0000269PubMed:19015314, ECO:0000269PubMed:19680224, ECO:0000269PubMed:22872859}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 57 [view]
Protein-Protein 57 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0071339 MLL1 complex
Protein Structure and Domains
PDB ID
InterPro IPR003653 Peptidase C48, SUMO/Sentrin/Ubl1
PFAM PF02902
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H4L4
PhosphoSite PhosphoSite-Q9H4L4
TrEMBL J3KNH7
UniProt Splice Variant
Entrez Gene 26168
UniGene Hs.685791
RefSeq
HUGO HGNC:17862
OMIM 612844
CCDS CCDS73958
HPRD 08339
IMGT
EMBL AC016876 AF199459 AL050283 AL834294 AY008763 BC048306 BC080658
GenPept AAG33252 AAH48306 AAH80658 AAL25652 CAB43384 CAD38967

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca