InnateDB Protein
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IDBP-365889.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HRH4
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Protein Name
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histamine receptor H4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000402526
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InnateDB Gene
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IDBG-1754 (HRH4)
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Protein Structure
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Function |
The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist). {ECO:0000269PubMed:12503632}.
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Subcellular Localization |
Cell membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node. {ECO:0000269PubMed:12503632}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004930
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G-protein coupled receptor activity
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GO:0004969
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histamine receptor activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like
IPR017452
GPCR, rhodopsin-like, 7TM
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PFAM |
PF00001
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PRINTS |
PR00237
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H3N8
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PhosphoSite |
PhosphoSite-Q9H3N8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
59340
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UniGene |
Hs.287388
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RefSeq |
NP_001137300
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HUGO |
HGNC:17383
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OMIM |
606792
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CCDS |
CCDS45841
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HPRD |
06004
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IMGT |
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EMBL |
AB044934
AB045370
AC007922
AF307973
AF312230
AF325356
AF329449
AJ298292
AY136745
BC069136
BC112348
CH471088
DQ835186
EF444982
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GenPept |
AAG32052
AAH69136
AAI12349
AAK12081
AAK43542
AAL01684
AAN01271
ABI54174
ACA05997
BAB13698
BAB20091
CAC83493
EAX01189
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