InnateDB Protein
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IDBP-365928.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ETS2
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Protein Name
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v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
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Synonyms
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ETS2IT1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000401273
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InnateDB Gene
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IDBG-3306 (ETS2)
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Protein Structure
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Function |
Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. {ECO:0000269PubMed:11909962}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
42
[view]
|
Protein-Protein |
36
[view]
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Protein-DNA |
5
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0000981
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sequence-specific DNA binding RNA polymerase II transcription factor activity
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GO:0001078
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0001501
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skeletal system development
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0030154
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cell differentiation
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GO:0045893
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positive regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
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InterPro |
IPR003118
Pointed domain
IPR013761
Sterile alpha motif/pointed domain
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PFAM |
PF02198
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PRINTS |
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PIRSF |
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SMART |
SM00251
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TIGRFAMs |
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Modification |
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SwissProt |
P15036
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PhosphoSite |
PhosphoSite-P15036
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
2114
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UniGene |
Hs.716040
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RefSeq |
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HUGO |
HGNC:3489
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OMIM |
164740
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CCDS |
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HPRD |
01263
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IMGT |
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EMBL |
AF017257
AK315563
AL163278
AP001040
AP001732
BC017040
BC042954
BT006838
CH471079
J04102
M11922
X55181
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GenPept |
AAA52411
AAA52412
AAB94057
AAH17040
AAH42954
AAP35484
BAA95514
BAG37939
CAA38966
CAB90468
EAX09673
EAX09674
EAX09676
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