Homo sapiens Protein: ZFAT
Summary
InnateDB Protein IDBP-36606.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFAT
Protein Name zinc finger and AT hook domain containing
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000367069
InnateDB Gene IDBG-36602 (ZFAT)
Protein Structure
UniProt Annotation
Function May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 1 is strongly expressed in placenta, spleen, kidney, testis and peripheral blood leukocytes. Expressed in CD4+ and CD8+ T-cells, CD19+ B-cells and CB14+ monocytes. Isoform 3 is strongly expressed in placenta, ovary, tonsil, CD19+ B-cells and CD14+ monocytes. {ECO:0000269PubMed:15294872}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006351 transcription, DNA-templated
GO:0030097 hemopoiesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060712 spongiotrophoblast layer development
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P243
PhosphoSite PhosphoSite-Q9P243
TrEMBL
UniProt Splice Variant
Entrez Gene 57623
UniGene Hs.446172
RefSeq NP_065914
HUGO HGNC:19899
OMIM 610931
CCDS CCDS47924
HPRD 11712
IMGT
EMBL AB040918 AB167738 AB167739 AB167740 AB167741 AC015599 AC087045 AC135075 BC025423 BC046180 BC101766 BC101768 BC143519
GenPept AAH25423 AAH46180 AAI01767 AAI01769 AAI43520 BAA96009 BAD12567 BAD12568 BAD12569 BAD12570