InnateDB Protein
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IDBP-36606.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ZFAT
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Protein Name
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zinc finger and AT hook domain containing
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000367069
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InnateDB Gene
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IDBG-36602 (ZFAT)
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Protein Structure
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Function |
May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is strongly expressed in placenta, spleen, kidney, testis and peripheral blood leukocytes. Expressed in CD4+ and CD8+ T-cells, CD19+ B-cells and CB14+ monocytes. Isoform 3 is strongly expressed in placenta, ovary, tonsil, CD19+ B-cells and CD14+ monocytes. {ECO:0000269PubMed:15294872}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0003677
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DNA binding
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
Q9P243
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PhosphoSite |
PhosphoSite-Q9P243
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
57623
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UniGene |
Hs.446172
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RefSeq |
NP_065914
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HUGO |
HGNC:19899
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OMIM |
610931
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CCDS |
CCDS47924
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HPRD |
11712
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IMGT |
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EMBL |
AB040918
AB167738
AB167739
AB167740
AB167741
AC015599
AC087045
AC135075
BC025423
BC046180
BC101766
BC101768
BC143519
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GenPept |
AAH25423
AAH46180
AAI01767
AAI01769
AAI43520
BAA96009
BAD12567
BAD12568
BAD12569
BAD12570
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