InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TUSC2

Summary

InnateDB Protein

IDBP-36612.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TUSC2

Protein Name

tumor suppressor candidate 2

Synonyms

C3orf11; FUS1; PAP; PDAP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000232496

InnateDB Gene

IDBG-36610 (TUSC2)

Protein Structure

UniProt Annotation

Function

May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.

Subcellular Localization

Disease Associations

Tissue Specificity

Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001779	natural killer cell differentiation
GO:0006909	phagocytosis
GO:0006954	inflammatory response
GO:0007049	cell cycle
GO:0007267	cell-cell signaling
GO:0008283	cell proliferation
GO:0032618	interleukin-15 production
GO:0032700	negative regulation of interleukin-17 production
GO:0032733	positive regulation of interleukin-10 production
GO:0048469	cell maturation
GO:0050829	defense response to Gram-negative bacterium
GO:0051881	regulation of mitochondrial membrane potential
GO:0052567	response to defense-related host reactive oxygen species production
GO:0070945	neutrophil mediated killing of gram-negative bacterium
GO:0071609	chemokine (C-C motif) ligand 5 production
GO:2000377	regulation of reactive oxygen species metabolic process