InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KDM6B

Summary

InnateDB Protein

IDBP-366670.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDM6B

Protein Name

lysine (K)-specific demethylase 6B

Synonyms

JMJD3;

Species

Homo sapiens

Ensembl Protein

ENSP00000412513

InnateDB Gene

IDBG-26897 (KDM6B)

Protein Structure

UniProt Annotation

Function

Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. {ECO:0000269PubMed:17825402, ECO:0000269PubMed:17851529}.

Subcellular Localization

Nucleus {ECO:0000305PubMed:17825402}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity
GO:0071558	histone demethylase activity (H3-K27 specific)

Biological Process

GO:0006954	inflammatory response
GO:0045446	endothelial cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048333	mesodermal cell differentiation
GO:0055007	cardiac muscle cell differentiation
GO:0055114	oxidation-reduction process
GO:0071557	histone H3-K27 demethylation