Version 5.4
Homo sapiens Gene: KDM6B
Summary
InnateDB Gene IDBG-26897.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KDM6B
Gene Name lysine (K)-specific demethylase 6B
Synonyms JMJD3
Species Homo sapiens
Ensembl Gene ENSG00000132510
Encoded Proteins
IDBP-26899
lysine (K)-specific demethylase 6B
IDBP-366670
lysine (K)-specific demethylase 6B
IDBP-761853
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7839904-7854796
Strand Forward strand
Band p13.1
Transcripts
ENST00000254846 ENSP00000254846
ENST00000448097 ENSP00000412513
ENST00000572030
ENST00000575521
ENST00000571047
ENST00000570632 ENSP00000458445
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
GO:0071558 histone demethylase activity (H3-K27 specific)
Biological Process
GO:0006954 inflammatory response
GO:0016577 histone demethylation
GO:0045446 endothelial cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048333 mesodermal cell differentiation
GO:0055007 cardiac muscle cell differentiation
GO:0055114 oxidation-reduction process
GO:0070301 cellular response to hydrogen peroxide
GO:0071557 histone H3-K27 demethylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018476
View Gene Order
ENSBTAG00000048062
Not yet available
Pathways
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_228178
HDMs demethylate histones pathway
REACT_169274
Cellular Senescence pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O15054
TrEMBL D3DTQ7 I3L0Z0
UniProt Splice Variant
Entrez Gene 23135
UniGene Hs.223678 Hs.730881
RefSeq NM_001080424 XM_005256549 XM_005256550 XM_005256551 XM_005256552 XM_005256554 XM_006721483
HUGO HGNC:29012
OMIM 611577
CCDS CCDS32552
HPRD
IMGT
EMBL AB002344 AC104581 BC009994 CH471108
GenPept AAH09994 BAA21572 EAW90127 EAW90128
RNA Seq Atlas 23135

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca