Version 5.4
Homo sapiens Protein: CLEC2A
Summary
InnateDB Protein IDBP-366750.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLEC2A
Protein Name C-type lectin domain family 2, member A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000396163
InnateDB Gene IDBG-18208 (CLEC2A)
Protein Structure
UniProt Annotation
Function Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti- apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity. {ECO:0000269PubMed:18550855, ECO:0000269PubMed:20194751}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:18046548, ECO:0000269PubMed:18550855}; Single-pass type II membrane protein {ECO:0000269PubMed:18046548, ECO:0000269PubMed:18550855}.
Disease Associations
Tissue Specificity Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine, peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8(+), B-lymphocytes and naive CD4(+) T-cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer (NK) cells. {ECO:0000269PubMed:18046548, ECO:0000269PubMed:18550855, ECO:0000269PubMed:20194751}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0042267 natural killer cell mediated cytotoxicity
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001304 C-type lectin
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UVW9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 387836
UniGene Hs.527665
RefSeq NP_001124183
HUGO HGNC:24191
OMIM 612087
CCDS CCDS44829
HPRD 16720
IMGT
EMBL AY359126 EF127467 EU095393 EU095394
GenPept AAQ89483 ABO33172 ABW79912 ABW79913

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca