InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TMPRSS2

Summary

InnateDB Protein

IDBP-367208.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMPRSS2

Protein Name

transmembrane protease, serine 2

Synonyms

PP9284; PRSS10;

Species

Homo sapiens

Ensembl Protein

ENSP00000391216

InnateDB Gene

IDBG-3965 (TMPRSS2)

Protein Structure

UniProt Annotation

Function

Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus- cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L- independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. {ECO:0000269PubMed:21068237, ECO:0000269PubMed:21325420, ECO:0000269PubMed:23536651, ECO:0000269PubMed:23966399, ECO:0000269PubMed:24027332, ECO:0000269PubMed:24227843}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:20382709, ECO:0000269PubMed:21068237}; Single-pass type II membrane protein {ECO:0000269PubMed:20382709, ECO:0000269PubMed:21068237}.Transmembrane protease serine 2 catalytic chain: Secreted. Note=Activated by cleavage and secreted.

Disease Associations

Tissue Specificity

Highly expressed in prostate epithelial cells and in prostate cancers. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly in small intestine. Also expressed in colon, stomach and salivary gland. {ECO:0000269PubMed:11169526, ECO:0000269PubMed:20382709, ECO:0000269PubMed:21325420}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006898	receptor-mediated endocytosis
GO:0016540	protein autoprocessing
GO:0046598	positive regulation of viral entry into host cell

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001190 SRCR domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel
IPR017448 SRCR-like domain

PFAM

PF00530
PF00089
PF00057
PF09342

PRINTS

PR00258
PR00722
PR00261

PIRSF

SMART

SM00020
SM00192
SM00202

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt