InnateDB Protein
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IDBP-367528.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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INSC
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Protein Name
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inscuteable homolog (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000389161
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InnateDB Gene
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IDBG-33444 (INSC)
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Protein Structure
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Function |
May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium. {ECO:0000269PubMed:16458856}.
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Subcellular Localization |
Cytoplasm. Note=Localizes to the apical cortex of mitotic epidermal cells and to the apical side of neuronal progenitor cells. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is expressed in various tissues with stronger expression in liver, kidney and small intestine. Isoform 2 is abundantly expressed in small intestine and to a lower extent in lung and pancreas. {ECO:0000269PubMed:12469229, ECO:0000269PubMed:16458856}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000225
Armadillo
IPR016024
Armadillo-type fold
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PFAM |
PF00514
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PRINTS |
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PIRSF |
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SMART |
SM00185
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TIGRFAMs |
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Modification |
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SwissProt |
Q1MX18
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PhosphoSite |
PhosphoSite-Q1MX18
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
387755
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UniGene |
Hs.591997
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RefSeq |
NP_001265243
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HUGO |
HGNC:33116
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OMIM |
610668
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AB231744
AB231745
AB231746
AB231747
AB231748
AB236158
AB236159
AC090744
BC127700
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GenPept |
AAI27701
BAE17133
BAE17134
BAE17135
BAE17136
BAE46891
BAE93463
BAE93464
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