InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FOXN1

Summary

InnateDB Protein

IDBP-36754.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXN1

Protein Name

forkhead box N1

Synonyms

FKHL20; RONU; WHN;

Species

Homo sapiens

Ensembl Protein

ENSP00000226247

InnateDB Gene

IDBG-36752 (FOXN1)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator involved in development.

Subcellular Localization

Nucleus.

Disease Associations

T-cell immunodeficiency, congenital alopecia, and nail dystrophy (TIDAND) [MIM:601705]: A disorder characterized by the association of congenital alopecia, severe T-cell immunodeficiency, and ridging and pitting of all nails. {ECO:0000269PubMed:10206641}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001942	hair follicle development
GO:0002260	lymphocyte homeostasis
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006952	defense response
GO:0008283	cell proliferation
GO:0008544	epidermis development
GO:0009887	organ morphogenesis
GO:0030216	keratinocyte differentiation
GO:0033081	regulation of T cell differentiation in thymus
GO:0035878	nail development
GO:0048538	thymus development
GO:0050673	epithelial cell proliferation