InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FOXN1

Summary

InnateDB Gene

IDBG-36752.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXN1

Gene Name

forkhead box N1

Synonyms

FKHL20; RONU; WHN

Species

Homo sapiens

Ensembl Gene

ENSG00000109101

Encoded Proteins

IDBP-36754

forkhead box N1

IDBP-764793

IDBP-762984

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008]
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5\' UTR of this gene has been observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:28506243-28538896

Strand

Forward strand

Band

q11.2

Transcripts

ENST00000226247	ENSP00000226247
ENST00000577936	ENSP00000462159
ENST00000579795	ENSP00000464645

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001942	hair follicle development
GO:0002260	lymphocyte homeostasis
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006952	defense response
GO:0008283	cell proliferation
GO:0008544	epidermis development
GO:0009887	organ morphogenesis
GO:0030216	keratinocyte differentiation
GO:0033081	regulation of T cell differentiation in thymus
GO:0035878	nail development
GO:0048538	thymus development
GO:0050673	epithelial cell proliferation

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000002057

View Gene Order

ENSBTAG00000013095

Not yet available

Cross-References

SwissProt

O15353

TrEMBL

J3KRT9

UniProt Splice Variant

Entrez Gene

8456

UniGene

Hs.58611 Hs.663679

RefSeq

NM_003593 XM_005258046

HUGO

HGNC:12765

OMIM

600838

CCDS

CCDS11232

HPRD

IMGT

EMBL

AC005726 AC015917 AK313878 CH471159 Y11739 Y11741 Y11742 Y11743 Y11744 Y11745 Y11746

GenPept

BAG36604 CAA72416 CAA72417 EAW51092

RNA Seq Atlas

8456