Homo sapiens Protein: DCTN3
Summary
InnateDB Protein IDBP-367631.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCTN3
Protein Name dynactin 3 (p22)
Synonyms DCTN-22; DCTN22;
Species Homo sapiens
Ensembl Protein ENSP00000390842
InnateDB Gene IDBG-60175 (DCTN3)
Protein Structure
UniProt Annotation
Function Together with dynein may be involved in spindle assembly and cytokinesis. {ECO:0000269PubMed:9722614}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:9722614}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:9722614}. Chromosome, centromere, kinetochore {ECO:0000269PubMed:9722614}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:9722614}. Cleavage furrow {ECO:0000269PubMed:9722614}. Midbody {ECO:0000269PubMed:9722614}. Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells.
Disease Associations
Tissue Specificity Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain. {ECO:0000269PubMed:9722614}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 22 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Protein Structure and Domains
PDB ID
InterPro IPR009991 Dynactin subunit p22
PFAM PF07426
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-O75935
TrEMBL X6RCK5
UniProt Splice Variant
Entrez Gene 11258
UniGene Hs.737671
RefSeq
HUGO HGNC:2713
OMIM 607387
CCDS
HPRD 06303
IMGT
EMBL AL160270 AL450283
GenPept