Version 5.4
Homo sapiens Protein: PGLS
Summary
InnateDB Protein IDBP-36780.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PGLS
Protein Name 6-phosphogluconolactonase
Synonyms 6PGL;
Species Homo sapiens
Ensembl Protein ENSP00000252603
InnateDB Gene IDBG-36778 (PGLS)
Protein Structure
UniProt Annotation
Function Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0017057 6-phosphogluconolactonase activity
GO:0048029 monosaccharide binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006098 pentose-phosphate shunt
GO:0009051 pentose-phosphate shunt, oxidative branch
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR005900 6-phosphogluconolactonase, DevB-type
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95336
PhosphoSite PhosphoSite-O95336
TrEMBL
UniProt Splice Variant
Entrez Gene 25796
UniGene
RefSeq NP_036220
HUGO HGNC:8903
OMIM 604951
CCDS CCDS12361
HPRD 12001
IMGT
EMBL AF091091 AJ243972 BC014006
GenPept AAC72960 AAH14006 CAB57866

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca