InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL11RA

Summary

InnateDB Protein

IDBP-367864.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL11RA

Protein Name

interleukin 11 receptor, alpha

Synonyms

CRSDA;

Species

Homo sapiens

Ensembl Protein

ENSP00000394391

InnateDB Gene

IDBG-60488 (IL11RA)

Protein Structure

UniProt Annotation

Function

Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. {ECO:0000269PubMed:21741611}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Craniosynostosis and dental anomalies (CRSDA) [MIM:614188]: A disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly. {ECO:0000269PubMed:21741611}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2. Also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma. {ECO:0000269PubMed:11141475}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004888	transmembrane signaling receptor activity
GO:0004896	cytokine receptor activity
GO:0005515	protein binding