Version 5.4
Homo sapiens Gene: IL11RA
Summary
InnateDB Gene IDBG-60488.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL11RA
Gene Name interleukin 11 receptor, alpha
Synonyms CRSDA
Species Homo sapiens
Ensembl Gene ENSG00000137070
Encoded Proteins
IDBP-60498
interleukin 11 receptor, alpha
IDBP-367864
interleukin 11 receptor, alpha
IDBP-586359
interleukin 11 receptor, alpha
IDBP-588575
interleukin 11 receptor, alpha
IDBP-586072
interleukin 11 receptor, alpha
IDBP-593222
interleukin 11 receptor, alpha
IDBP-587719
interleukin 11 receptor, alpha
IDBP-584663
interleukin 11 receptor, alpha
IDBP-593519
interleukin 11 receptor, alpha
IDBP-602561
interleukin 11 receptor, alpha
IDBP-811958
interleukin 11 receptor, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:34650702-34661892
Strand Forward strand
Band p13.3
Transcripts
ENST00000318041 ENSP00000326500
ENST00000441545 ENSP00000394391
ENST00000478308
ENST00000478802
ENST00000466082 ENSP00000432263
ENST00000555003 ENSP00000450565
ENST00000555247 ENSP00000450707
ENST00000553620 ENSP00000452207
ENST00000556792 ENSP00000450543
ENST00000557298 ENSP00000451553
ENST00000556531 ENSP00000451447
ENST00000555981 ENSP00000450640
ENST00000555579
ENST00000553969
ENST00000602473 ENSP00000473647
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 5 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007566 embryo implantation
GO:0019221 cytokine-mediated signaling pathway
GO:0032502 developmental process
GO:0060322 head development
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000073889
View Gene Order
ENSBTAG00000014907
Not yet available
Pathways
NETPATH
NetPath_147
IL11 pathway
REACTOME
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591088
RefSeq NM_001142784
HUGO
OMIM
CCDS CCDS6567
HPRD 02965
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca