Version 5.4
Homo sapiens Protein: NEBL
Summary
InnateDB Protein IDBP-368717.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEBL
Protein Name nebulette
Synonyms LASP2; LNEBL;
Species Homo sapiens
Ensembl Protein ENSP00000393896
InnateDB Gene IDBG-60402 (NEBL)
Protein Structure
UniProt Annotation
Function Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion. {ECO:0000269PubMed:15004028}.
Subcellular Localization Isoform 2: Cytoplasm {ECO:0000269PubMed:15004028}.
Disease Associations
Tissue Specificity Abundantly expressed in cardiac muscle, but not in skeletal or smooth muscle. Localized to Z-lines in cardiac cells and to dense bodies in nonmuscle cells. Isoform 2 is expressed in non-muscle cells such as in fibroblasts.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005523 tropomyosin binding
GO:0008092 cytoskeletal protein binding
GO:0008270 zinc ion binding
GO:0008307 structural constituent of muscle
GO:0031005 filamin binding
GO:0051015 actin filament binding
Biological Process
GO:0071691 cardiac muscle thin filament assembly
Cellular Component
GO:0001725 stress fiber
GO:0030018 Z disc
GO:0031674 I band
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000900 Nebulin repeat
IPR001452 SH3 domain
IPR001781 Zinc finger, LIM-type
IPR011511 Variant SH3 domain
PFAM PF00880
PF00018
PF14604
PF00412
PF07653
PRINTS PR00452
PIRSF
SMART SM00227
SM00326
SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O76041
PhosphoSite PhosphoSite-O76041
TrEMBL B7ZB56
UniProt Splice Variant
Entrez Gene 10529
UniGene Hs.609027
RefSeq NP_998734
HUGO HGNC:16932
OMIM 605491
CCDS CCDS7133
HPRD 10403
IMGT
EMBL AF047368 AJ580772 AK295186 AK316521 AL157398 AL158160 AL359175 AL731547 BC110453 BC126132 BC126134 CH471072 EF445000 Y16241 Y17673
GenPept AAF24858 AAI10454 AAI26133 AAI26135 ACA06022 ACA06023 ACA06024 ACA06026 BAG58190 BAH14892 CAA76130 CAA76810 CAC19642 CAE45323 CAH71371 CAI15775 CAI41189 EAW86175

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca