InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STYX

Summary

InnateDB Protein

IDBP-369063.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STYX

Protein Name

serine/threonine/tyrosine interacting protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000403214

InnateDB Gene

IDBG-6868 (STYX)

Protein Structure

UniProt Annotation

Function

Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). Seems to play a role in spermiogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:23847209}. Cytoplasm, cytosol {ECO:0000269PubMed:23847209}. Note=Little staining visible in the cytosol.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0007283	spermatogenesis
GO:0016311	dephosphorylation
GO:0045204	MAPK export from nucleus
GO:0070372	regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00782

PRINTS

PIRSF

SMART

SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8WUJ0