InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDKN3

Summary

InnateDB Protein

IDBP-369294.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDKN3

Protein Name

cyclin-dependent kinase inhibitor 3

Synonyms

CDI1; CIP2; KAP; KAP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000415333

InnateDB Gene

IDBG-6996 (CDKN3)

Protein Structure

UniProt Annotation

Function

May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner. {ECO:0000269PubMed:7569954, ECO:0000269PubMed:8127873, ECO:0000269PubMed:8242750}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000269PubMed:10669749}.

Disease Associations

Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. {ECO:0000269PubMed:10987270}. Note=The gene represented in this entry may be involved in disease pathogenesis.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0006470	protein dephosphorylation
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR008425 Cyclin-dependent kinase inhibitor 3
IPR022778 CDKN3 domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00782
PF05706

PRINTS

PR00700

PIRSF

PIRSF037322

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References