InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TARBP2

Summary

InnateDB Protein

IDBP-36940.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TARBP2

Protein Name

TAR (HIV-1) RNA binding protein 2

Synonyms

LOQS; TRBP; TRBP1; TRBP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000266987

InnateDB Gene

IDBG-36938 (TARBP2)

Protein Structure

UniProt Annotation

Function

Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR. {ECO:0000269PubMed:12475984, ECO:0000269PubMed:15973356, ECO:0000269PubMed:16142218, ECO:0000269PubMed:16271387, ECO:0000269PubMed:16357216, ECO:0000269PubMed:16424907, ECO:0000269PubMed:17452327, ECO:0000269PubMed:18178619, ECO:0000269PubMed:19219043}.

Subcellular Localization

Cytoplasm. Cytoplasm, perinuclear region. Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	56 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0035197	siRNA binding
GO:0035198	miRNA binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006417	regulation of translation
GO:0006469	negative regulation of protein kinase activity
GO:0010467	gene expression
GO:0030422	production of siRNA involved in RNA interference
GO:0030423	targeting of mRNA for destruction involved in RNA interference
GO:0031054	pre-miRNA processing
GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA
GO:0045070	positive regulation of viral genome replication
GO:0046782	regulation of viral transcription
GO:0050689	negative regulation of defense response to virus by host