Version 5.4
Homo sapiens Gene: TARBP2
Summary
InnateDB Gene IDBG-36938.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TARBP2
Gene Name TAR (HIV-1) RNA binding protein 2
Synonyms LOQS; TRBP; TRBP1; TRBP2
Species Homo sapiens
Ensembl Gene ENSG00000139546
Encoded Proteins
IDBP-36940
TAR (HIV-1) RNA binding protein 2
IDBP-241745
TAR (HIV-1) RNA binding protein 2
IDBP-376475
TAR (HIV-1) RNA binding protein 2
IDBP-592379
TAR (HIV-1) RNA binding protein 2
IDBP-588746
TAR (HIV-1) RNA binding protein 2
IDBP-584806
TAR (HIV-1) RNA binding protein 2
IDBP-592899
TAR (HIV-1) RNA binding protein 2
IDBP-586559
TAR (HIV-1) RNA binding protein 2
IDBP-717842
IDBP-589139
TAR (HIV-1) RNA binding protein 2
IDBP-602929
TAR (HIV-1) RNA binding protein 2
IDBP-601452
TAR (HIV-1) RNA binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:53500921-53506431
Strand Forward strand
Band q13.13
Transcripts
ENST00000266987 ENSP00000266987
ENST00000394357 ENSP00000377885
ENST00000456234 ENSP00000416077
ENST00000550147 ENSP00000450320
ENST00000552857 ENSP00000449537
ENST00000549610
ENST00000546889
ENST00000548971 ENSP00000447993
ENST00000547388
ENST00000552650
ENST00000547064 ENSP00000448199
ENST00000551741 ENSP00000447262
ENST00000552817 ENSP00000458011
ENST00000549028
ENST00000549572 ENSP00000448948
ENST00000549679 ENSP00000448943
ENST00000550407 ENSP00000447767
ENST00000551157
ENST00000547541
ENST00000546763
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 57 [view]
Protein-Protein 56 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
GO:0005515 protein binding
GO:0035197 siRNA binding
GO:0035198 miRNA binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006417 regulation of translation
GO:0006469 negative regulation of protein kinase activity
GO:0010467 gene expression
GO:0030422 production of siRNA involved in RNA interference
GO:0030423 targeting of mRNA for destruction involved in RNA interference
GO:0031054 pre-miRNA processing
GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA
GO:0045070 positive regulation of viral genome replication
GO:0046782 regulation of viral transcription
GO:0050689 negative regulation of defense response to virus by host
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016442 RISC complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023051
View Gene Order
ENSBTAG00000000435
Not yet available
Pathways
NETPATH
REACTOME
REACT_12417
MicroRNA (miRNA) biogenesis pathway
REACT_118560
Small interfering RNA (siRNA) biogenesis pathway
REACT_71
Gene Expression pathway
REACT_12472
Regulatory RNA pathways pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.326
RefSeq NM_004178 NM_134323 NM_134324 XM_005269114 XM_005269115 XM_005269117 XM_005269120 XM_005269122 XM_006719581
HUGO
OMIM
CCDS CCDS41791 CCDS8861
HPRD 05446
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca