InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIF18A

Summary

InnateDB Protein

IDBP-36960.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF18A

Protein Name

kinesin family member 18A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000263181

InnateDB Gene

IDBG-36958 (KIF18A)

Protein Structure

UniProt Annotation

Function

Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. {ECO:0000269PubMed:17346968, ECO:0000269PubMed:18267093, ECO:0000269PubMed:18513970, ECO:0000269PubMed:19625775}.

Subcellular Localization

Cell projection, ruffle. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0008574	plus-end-directed microtubule motor activity
GO:0043130	ubiquitin binding
GO:0051010	microtubule plus-end binding
GO:0070463	tubulin-dependent ATPase activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0006200	ATP catabolic process
GO:0007018	microtubule-based movement
GO:0007019	microtubule depolymerization
GO:0007080	mitotic metaphase plate congression
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0015031	protein transport
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005828	kinetochore microtubule
GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0005901	caveola
GO:0015630	microtubule cytoskeleton