InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GAS2

Summary

InnateDB Protein

IDBP-369691.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAS2

Protein Name

growth arrest-specific 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000401145

InnateDB Gene

IDBG-36228 (GAS2)

Protein Structure

UniProt Annotation

Function

May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth- arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0007050	cell cycle arrest
GO:0008360	regulation of cell shape