InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SOX5

Summary

InnateDB Protein

IDBP-369739.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOX5

Protein Name

SRY (sex determining region Y)-box 5

Synonyms

L-SOX5; L-SOX5B; L-SOX5F;

Species

Homo sapiens

Ensembl Protein

ENSP00000398273

InnateDB Gene

IDBG-23504 (SOX5)

Protein Structure

UniProt Annotation

Function

Binds specifically to the DNA sequence 5'-AACAAT-3'. Activates transcription of COL2A1 and AGC1 in vitro.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00267}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	18 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001701	in utero embryonic development
GO:0006366	transcription from RNA polymerase II promoter
GO:0021953	central nervous system neuron differentiation
GO:0032332	positive regulation of chondrocyte differentiation
GO:0045165	cell fate commitment
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048709	oligodendrocyte differentiation
GO:0051216	cartilage development
GO:0060164	regulation of timing of neuron differentiation
GO:0061036	positive regulation of cartilage development
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:2000741	positive regulation of mesenchymal stem cell differentiation